Enzymes associated to oral toxicity in haematopoietic cell transplantation

biomolecularint

Salivary antioxidant enzymes associated to oral toxicity in haematopoietic cell transplantation: An observational analysis

 

Background: In haematopoietic cell transplantation (HCT), oral mucositis and xerostomia are related to conditioning-related oxidative stress. The perform of salivary antioxidant enzymes in oral toxicity is poorly described. The aim of this analysis was to substantiate the affiliation between salivary antioxidant enzymes and oral mucositis and xerostomia in HCT.

 

Design: Saliva from autologous and allogeneic HCT victims (n = 77) was chosen sooner than conditioning (T0), in the midst of the neutropenia interval (T1) and after marrow engraftment (T2). Salivary flow into, full salivary proteins, and superoxide dismutase, catalase and glutathione reductase actions had been measured.

 

Outcomes: There have been no vital variations in salivary flow into, full salivary proteins and catalase on the three HCT time components. Glutathione reductase ranges had been diminished at T1 compared with T0 (P = .013) and T2 (P = .001). Superoxide dismutase ranges had been elevated from T0 to T2 (P = .013). Neither of these enzymes was associated to oral mucositis. Elevated superoxide dismutase ranges had been associated to xerostomia frequency. Ranges of this enzyme moreover confirmed vital correlation with days of xerostomia in T2 (ρ = .40, P = .002).

 

Conclusions: Salivary antioxidant enzymes modified sooner than and thru early durations after HCT. The rise in salivary superoxide dismutase suggested partial activation of the salivary antioxidant system and was associated to xerostomia.

 

biomolecularint

biomolecularint

Bovine mRNA- decapping enzyme 1B, DCP1B ELISA KIT

ELI-32403b 96tests
EUR 796

DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B)

MBS641446-02mL 0.2mL
EUR 695

DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B)

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EUR 2975

DCP1B (untagged)-Human DCP1 decapping enzyme homolog B (S. cerevisiae) (DCP1B)

SC126398 10 µg Ask for price

DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (AP)

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EUR 980

DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (AP)

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EUR 4250

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DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (PE)

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DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (FITC)

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DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (Biotin)

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Lenti ORF particles, Dcp1b (GFP-tagged) - Mouse DCP1 decapping enzyme homolog b (S. cerevisiae) (Dcp1b), 200ul, >10^7 TU/mL

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Human mRNA-decapping enzyme 1B (DCP1B)

1-CSB-YP811635HU
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Description: Recombinant Human mRNA-decapping enzyme 1B(DCP1B) expressed in Yeast

Human mRNA-decapping enzyme 1B (DCP1B)

1-CSB-CF811635HU
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Description: Recombinant Human mRNA-decapping enzyme 1B(DCP1B) expressed in in vitro E.coli expression system

mRNA-Decapping Enzyme 1B (DCP1B) Antibody

20-abx111966
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abx232270-100ug 100 ug
EUR 610.8

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mRNA-Decapping Enzyme 1B (DCP1B) Antibody

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DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (AP)

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EUR 950

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MBS7053565-002mg 0.02mg
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Recombinant Human mRNA-decapping enzyme 1B (DCP1B)

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EUR 1350

Recombinant Human mRNA-decapping enzyme 1B (DCP1B)

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EUR 5880

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Recombinant Human mRNA-decapping enzyme 1B (DCP1B)

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EUR 610

Recombinant Human mRNA-decapping enzyme 1B (DCP1B)

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EUR 1505

Recombinant Human mRNA-decapping enzyme 1B (DCP1B)

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EUR 6565

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EUR 1435

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EUR 1195

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EUR 1355

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EUR 1405

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EUR 440

Recombinant Human mRNA-decapping enzyme 1B (DCP1B)

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EUR 760

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EUR 1975

Recombinant Human mRNA-decapping enzyme 1B (DCP1B)

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EUR 8735

Lenti ORF clone of Human DCP1 decapping enzyme homolog B (S. cerevisiae) (DCP1B), Myc-DDK-tagged

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SC201741 10 µg Ask for price

Mouse mRNA- decapping enzyme 2, Dcp2 ELISA KIT

ELI-26523m 96tests
EUR 736

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EUR 696

Human mRNA-Decapping Enzyme 1B (DCP1B) ELISA Kit

abx386810-96tests 96 tests
EUR 1093.2

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EUR 687.5

Human mRNA-decapping enzyme 1B, DCP1B ELISA Kit

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Human mRNA-decapping enzyme 1B, DCP1B ELISA Kit

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EUR 950

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EUR 4120

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EUR 950

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EUR 4120

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MBS6413677-01mL 0.1mL
EUR 950

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EUR 4120

DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (MaxLight 650)

MBS6413678-01mL 0.1mL
EUR 950

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MBS6413678-5x01mL 5x0.1mL
EUR 4120

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MBS6413679-01mL 0.1mL
EUR 950

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EUR 4120

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MBS1321205-INQUIRE INQUIRE Ask for price

Rat Scavenger mRNA- decapping enzyme DcpS, Dcps ELISA KIT

ELI-32404r 96tests
EUR 756

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ELI-48380m 96tests
EUR 736

Human Scavenger mRNA- decapping enzyme DcpS, DCPS ELISA KIT

ELI-08941h 96tests
EUR 696

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EUR 796

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MG209319 10 µg Ask for price

Human Decapping Enzyme 2(DCP2)ELISA Kit

QY-E02926 96T
EUR 433.2

Human Decapping Enzyme 2 (DCP2) ELISA Kit

MBS9312948-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Decapping Enzyme 2 (DCP2) ELISA Kit

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EUR 550

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EUR 3420

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EUR 765

DCP2 (untagged)-Human DCP2 decapping enzyme homolog (S. cerevisiae) (DCP2)

SC100774 10 µg Ask for price

DCPS (untagged)-Human decapping enzyme, scavenger (DCPS)

SC319248 10 µg Ask for price

Dcp2 (untagged) - Mouse DCP2 decapping enzyme homolog (S. cerevisiae) (Dcp2), (10ug)

MC211089 10 µg Ask for price

DCP2 (GFP-tagged) - Human DCP2 decapping enzyme homolog (S. cerevisiae) (DCP2)

RG221165 10 µg Ask for price

DCP1A (untagged)-Human DCP1 decapping enzyme homolog A (S. cerevisiae) (DCP1A)

SC318001 10 µg Ask for price

DCP1A (untagged)-Human DCP1 decapping enzyme homolog A (S. cerevisiae) (DCP1A)

SC319488 10 µg Ask for price

Decapping Enzyme, Scavenger (DCPS) Antibody

20-abx125746
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Decapping Enzyme, Scavenger (DCPS) Antibody

abx029282-400ul 400 ul
EUR 627.6

Decapping Enzyme, Scavenger (DCPS) Antibody

abx029282-80l 80 µl
EUR 343.2

Dcp2 (untagged) - Rat decapping mRNA 2 (Dcp2)

RN216629 10 µg Ask for price

Dcp1a (untagged) - Rat decapping mRNA 1A (Dcp1a)

RN216983 10 µg Ask for price

Dcps (GFP-tagged) - Mouse decapping enzyme, scavenger (Dcps)

MG205053 10 µg Ask for price

DCPS (GFP-tagged) - Human decapping enzyme, scavenger (DCPS)

RG203052 10 µg Ask for price

Dcps (untagged) - Mouse decapping enzyme, scavenger (Dcps), (10ug)

MC203955 10 µg Ask for price

 

 

Tubulin modifying enzymes as objective for the remedy of tau-related illnesses

 

  • Inside the thoughts of victims with Alzheimer’s sickness (AD), the amount and dimension of microtubules (MTs) are significantly and selectively diminished. MTs are involved in quite a lot of cell options, and defects of the microtubular system have emerged as a unifying hypothesis for the heterogeneous and variable medical exhibits of AD.

 

  • MTs orchestrate their fairly a couple of options by the use of the spatiotemporal regulation of the binding of specialised microtubule-associated proteins (MAPs) and molecular motors. Covalent posttranslational modifications (PTMs) on the tubulin C-termini that protrude on the ground of MTs regulate the binding of these effectors.

 

  • In neurons, MAP tau may be very appreciable and its irregular dissociation from MTs throughout the axon, cell mislocalization and hyperphosphorylation, are most important events leading to neuronal dying. Consequently, compounds concentrating on tau phosphorylation or aggregation are at current evaluated nonetheless their medical significance has not been demonstrated On this evaluation, we deal with the rising hyperlink between tubulin PTMs and tau dysfunction. In neurons, extreme ranges of glutamylation and detyrosination profoundly impression the physicochemical properties on the ground of MTs.

 

  • Moreover, in victims with early-onset progressive neurodegeneration, deleterious mutations in enzymes involved in modifying MTs on the ground have simply currently been acknowledged, underscoring the importance of this enzymatic tools in neurology. We postulate that pharmacologically concentrating on the tubulin-modifying enzymes holds promise as therapeutic technique for the remedy of neurodegenerative illnesses.

 

Organoarsenicals inhibit bacterial peptidoglycan biosynthesis by concentrating on the vital enzymeMurA

Trivalent organoarsenicals similar to methylarsenite (MAs(III)) are considerably further toxic than inorganic arsenate (As(V)) or arsenite (As(III)). In microbial communities MAs(III) reveals vital antimicrobial train. Although MAs(III) and completely different organoarsenicals contribute to the worldwide arsenic biogeocycle, how they exert antibiotic-like properties is mainly unknown. To find out attainable targets of MAs(III), a genomic library of the gram-negative bacterium,

 

Shewanellaputrefaciens 200, was expressed in Escherichia coli with selection for MAs(III) resistance. One clone contained the S. putrefaciensmurA gene (SpmurA), which catalyzes the first devoted step in peptidoglycan biosynthesis. Overexpression of SpmurA conferred MAs(III) resistance to E. coli.

 

Purified SpMurA was inhibited by MAs(III), phenylarsenite (PhAs(III)) or the phosphonate antibiotic fosfomycin nonetheless not by inorganic As(III). Fosfomycin inhibits MurA by binding to a conserved residue that corresponds to Cys117 in SpMurA. A C117D mutant was proof in opposition to fosfomycin nonetheless remained delicate to MAs(III), indicating that the two compounds have completely completely different mechanisms of movement. New inhibitors of peptidoglycan biosynthesis are extraordinarily wished as antimicrobial medicine, and organoarsenicals characterize a new house for the occasion of novel compounds for combating the specter of antibiotic resistance.

 

ECE1 (Endothelin Converting Enzyme 1, ECE) (HRP)

MBS6414917-01mL 0.1mL
EUR 950

ECE1 (Endothelin Converting Enzyme 1, ECE) (HRP)

MBS6414917-5x01mL 5x0.1mL
EUR 4120

ECE1 (Endothelin Converting Enzyme 1, ECE) (FITC)

MBS6414916-01mL 0.1mL
EUR 950

ECE1 (Endothelin Converting Enzyme 1, ECE) (FITC)

MBS6414916-5x01mL 5x0.1mL
EUR 4120

ECE1 (Endothelin Converting Enzyme 1, ECE) (Biotin)

MBS6414915-01mL 0.1mL
EUR 950

ECE1 (Endothelin Converting Enzyme 1, ECE) (Biotin)

MBS6414915-5x01mL 5x0.1mL
EUR 4120

ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 405)

MBS6414918-01mL 0.1mL
EUR 950

ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 405)

MBS6414918-5x01mL 5x0.1mL
EUR 4120

ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 490)

MBS6414919-01mL 0.1mL
EUR 950

ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 490)

MBS6414919-5x01mL 5x0.1mL
EUR 4120

ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 550)

MBS6414920-01mL 0.1mL
EUR 950

ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 550)

MBS6414920-5x01mL 5x0.1mL
EUR 4120

ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 650)

MBS6414921-01mL 0.1mL
EUR 950

ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 650)

MBS6414921-5x01mL 5x0.1mL
EUR 4120

ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 750)

MBS6414922-01mL 0.1mL
EUR 950

ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 750)

MBS6414922-5x01mL 5x0.1mL
EUR 4120

Endothelin Converting Enzyme 1 (ECE1) Antibody

20-abx103137
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  • 100 ug
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  • 1 mg
  • 200 ug
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Endothelin Converting Enzyme 1 (ECE1) Antibody

20-abx103138
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  • 100 ug
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  • 200 ug
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Endothelin Converting Enzyme 1 (ECE1) Antibody

20-abx130012
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  • 100 ug
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Endothelin Converting Enzyme 1 (ECE1) Antibody

abx145201-100ug 100 ug
EUR 469.2

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx033018-400ul 400 ul
EUR 627.6

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx033018-80l 80 µl
EUR 343.2

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx033019-400ul 400 ul
EUR 627.6

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx033019-80l 80 µl
EUR 343.2

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx033020-400ul 400 ul
EUR 627.6

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx033020-80l 80 µl
EUR 343.2

Endothelin Converting Enzyme 1 (ECE1) Antibody

20-abx004310
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Endothelin Converting Enzyme 1 (ECE1) Antibody

20-abx214580
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  • 100 ul
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Endothelin Converting Enzyme 1 (ECE1) Antibody

20-abx214643
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  • 100 ul
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Endothelin Converting Enzyme 1 (ECE1) Antibody

20-abx172239
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  • 1 mg
  • 200 ug

Endothelin Converting Enzyme 1 (ECE1) Antibody

20-abx320177
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  • 100 ul
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Endothelin Converting Enzyme 1 (ECE1) Antibody

abx130012-100l 100 µl
EUR 262.5

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx130012-1ml 1 ml
EUR 725

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx130012-200l 200 µl
EUR 337.5

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx172239-1ml 1 ml
EUR 712.5

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx033018-400l 400 µl
EUR 518.75

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx033019-400l 400 µl
EUR 518.75

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx033020-400l 400 µl
EUR 518.75

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx145201-1096tests 10 × 96 tests Ask for price

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx145201-596tests 5 × 96 tests Ask for price

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx145201-96tests 96 tests
EUR 337.5

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx214580-100tests 100 tests
EUR 350

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx214580-200tests 200 tests Ask for price

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx214580-20tests 20 tests
EUR 250

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx214643-100tests 100 tests
EUR 350

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx214643-200tests 200 tests Ask for price

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx214643-20tests 20 tests
EUR 250

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx320177-100l 100 µl
EUR 350

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx320177-50l 50 µl
EUR 237.5

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx004310-100l 100 µl
EUR 475

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx004310-20l 20 µl
EUR 200

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx004310-50l 50 µl
EUR 325

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx103137-100l 100 µl
EUR 250

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx103137-1ml 1 ml
EUR 675

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx103137-200l 200 µl
EUR 312.5

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx103138-100l 100 µl
EUR 262.5

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx103138-1ml 1 ml
EUR 687.5

Endothelin Converting Enzyme 1 (ECE1) Antibody

abx103138-200l 200 µl
EUR 325

Recombinant Endothelin Converting Enzyme 1 (ECE1)

RPU54158-100ug 100ug
EUR 578.6

Recombinant Endothelin Converting Enzyme 1 (ECE1)

RPU54158-1mg 1mg
EUR 2566.2

Recombinant Endothelin Converting Enzyme 1 (ECE1)

RPU54158-50ug 50ug
EUR 465.3

Recombinant Endothelin Converting Enzyme 1 (ECE1)

RPU41273-100ug 100ug
EUR 517

Recombinant Endothelin Converting Enzyme 1 (ECE1)

RPU41273-1mg 1mg
EUR 2293.2

Recombinant Endothelin Converting Enzyme 1 (ECE1)

RPU41273-50ug 50ug
EUR 415.8

Recombinant Endothelin Converting Enzyme 1 (ECE1)

RPU41274-100ug 100ug
EUR 554.4

Recombinant Endothelin Converting Enzyme 1 (ECE1)

RPU41274-1mg 1mg
EUR 2457

Recombinant Endothelin Converting Enzyme 1 (ECE1)

RPU41274-50ug 50ug
EUR 445.5

Recombinant Endothelin Converting Enzyme 1 (ECE1)

RPA483Hu01 10ug
EUR 168

Recombinant Endothelin Converting Enzyme 1 (ECE1)

4-RPA483Hu01
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  • 100 ug
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  • 5 mg
Description: Recombinant Human Endothelin Converting Enzyme 1 expressed in: E.coli

Recombinant Endothelin Converting Enzyme 1 (ECE1)

RPA483Mu01 10ug
EUR 180

Recombinant Endothelin Converting Enzyme 1 (ECE1)

4-RPA483Mu01
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  • 100 ug
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  • 50ug
  • 5 mg
Description: Recombinant Mouse Endothelin Converting Enzyme 1 expressed in: E.coli

Recombinant Endothelin Converting Enzyme 1 (ECE1)

RPA483Ra01 10ug
EUR 188

Recombinant Endothelin Converting Enzyme 1 (ECE1)

4-RPA483Ra01
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  • 100 ug
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  • 5 mg
Description: Recombinant Rat Endothelin Converting Enzyme 1 expressed in: E.coli

Recombinant Endothelin Converting Enzyme 1 (ECE1)

MBS2030000-001mg 0.01mg
EUR 175

Recombinant Endothelin Converting Enzyme 1 (ECE1)

MBS2030000-005mg 0.05mg
EUR 320

Recombinant Endothelin Converting Enzyme 1 (ECE1)

MBS2030000-01mg 0.1mg
EUR 485

Recombinant Endothelin Converting Enzyme 1 (ECE1)

MBS2030000-02mg 0.2mg
EUR 600

Recombinant Endothelin Converting Enzyme 1 (ECE1)

MBS2030000-05mg 0.5mg
EUR 1135

Recombinant Endothelin Converting Enzyme 1 (ECE1)

MBS2009887-001mg 0.01mg
EUR 175

Recombinant Endothelin Converting Enzyme 1 (ECE1)

MBS2009887-005mg 0.05mg
EUR 310

Recombinant Endothelin Converting Enzyme 1 (ECE1)

MBS2009887-01mg 0.1mg
EUR 470

Recombinant Endothelin Converting Enzyme 1 (ECE1)

MBS2009887-02mg 0.2mg
EUR 575

Recombinant Endothelin Converting Enzyme 1 (ECE1)

MBS2009887-05mg 0.5mg
EUR 1090

Recombinant Endothelin Converting Enzyme 1 (ECE1)

MBS2009889-001mg 0.01mg
EUR 170

Recombinant Endothelin Converting Enzyme 1 (ECE1)

MBS2009889-005mg 0.05mg
EUR 295

Recombinant Endothelin Converting Enzyme 1 (ECE1)

MBS2009889-01mg 0.1mg
EUR 445

Recombinant Endothelin Converting Enzyme 1 (ECE1)

MBS2009889-02mg 0.2mg
EUR 540

Recombinant Endothelin Converting Enzyme 1 (ECE1)

MBS2009889-05mg 0.5mg
EUR 1025

Ece1 (GFP-tagged) - Mouse endothelin converting enzyme 1 (Ece1)

MG210476 10 µg Ask for price

Rat Endothelin Converting Enzyme 1 (ECE1) Protein

20-abx168533
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Endothelin Converting Enzyme 1 (ECE1) Protein

abx168533-1ml 1 ml
EUR 237.5

Ece1 (untagged) - Mouse endothelin converting enzyme 1 (Ece1), (10ug)

MC221329 10 µg Ask for price

Human Endothelin Converting Enzyme 1 (ECE1) Protein

20-abx066416
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  • 100 ug
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Mouse Endothelin Converting Enzyme 1 (ECE1) Protein

20-abx066417
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  • 100 ug
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  • 200 ug
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Human Endothelin Converting Enzyme 1 (ECE1) Protein

abx066416-100g 100 µg
EUR 550

Human Endothelin Converting Enzyme 1 (ECE1) Protein

abx066416-10g 10 µg
EUR 212.5

Human Endothelin Converting Enzyme 1 (ECE1) Protein

abx066416-50g 50 µg
EUR 387.5

Mouse Endothelin Converting Enzyme 1 (ECE1) Protein

abx066417-100g 100 µg
EUR 587.5

Mouse Endothelin Converting Enzyme 1 (ECE1) Protein

abx066417-10g 10 µg
EUR 225

Mouse Endothelin Converting Enzyme 1 (ECE1) Protein

abx066417-50g 50 µg
EUR 400

ECE-1, Recombinant, Mouse (Endothelin Converting Enzyme-1)

MBS638185-001mg 0.01mg
EUR 875

ECE-1, Recombinant, Mouse (Endothelin Converting Enzyme-1)

MBS638185-5x001mg 5x0.01mg
EUR 3720

Cow Endothelin Converting Enzyme 1 (ECE1) ELISA Kit

abx521037-96tests 96 tests
EUR 1093.2

Rat Endothelin Converting Enzyme 1 (ECE1) ELISA Kit

abx521040-96tests 96 tests
EUR 886.8

Pig Endothelin Converting Enzyme 1 (ECE1) ELISA Kit

abx361861-96tests 96 tests
EUR 990

ELISA Kit for Endothelin Converting Enzyme 1 (ECE1)

SEA483Hu 96Т
EUR 630

 

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